Evaluate the Presence of Auto-Antibodies in Subjects with B- Thalassemia Major for Early Intervention to Decrease Morbidity and Mortality

This study was performed of evaluate the presence of auto antibodies and hypercoagulability in subjects with β -thalassemia major. Subjects (60) with – β-thalassemia major were involved in the current work. History background, clinical tests and laboratory investigation including anti-cardiolipin antibodies anti-histone antibodies, ANA and anti-erythropoietin antibodies by ELISA, Ferritin by Cobas e411, protein S, protein C, and anti-thromobin III anti-bodies via ELISA. Findings of the study showed that there is elevated frequency of auto-antibodies in thalassemia major subjects, ANA was positive in 13.3% of cases, anti-histone antibodies was positive in 3.3% of cases, anti-cardiolipin antibodies in 15% and ant erythropoietin in 93.3% of cases. Protein C activity was deficient in 26.6% and protein S was deficient in deficient anti-thrombin III activity.  Such abnormalities were not of significance associated to the HCV infection state or to the chelation type if subcutaneous or oral. Deficiency of protein C significantly existed in elder subjects.