Publication Details
Abstract
For this experiment, a novel thiazole-based chalcone ligand named MCT, that is, (Z)-1-(4-chlorophenyl)-3-(4-methylthiazol-5-yl)prop-2-en-1-one, was used to synthesize three complexes of Zn(II), [Zn(MCT)₂]Cl₂, [Zn(MCT)(dppe)]Cl₂, and [Zn(MCT)(dppp)]Cl₂. Characterization of the synthesized complexes was done via FT-IR, ¹H-NMR, and ³¹P{¹H}-NMR spectroscopies. According to the obtained FT-IR results, it was found that Zn(II) is coordinated to the MCT ligand by oxygen of the carbonyl group and the sulfur donor atom, while according to the ³¹P{¹H}-NMR spectra of complexes containing phosphine ligands, the phosphorus atoms are chemically equivalent in the complex structures because only one resonance for each phosphorus atom was revealed. In antibacterial screening assays against Escherichia coli and Staphylococcus aureus, different antibacterial activities dependent on the composition and concentration of complexes were detected. Thus, [Zn(MCT)(dppe)]Cl₂ was found to exhibit high activity against E. coli, and whereas [Zn(MCT)(dppp)]Cl₂ exhibited the most pronounced activity against S. aureus. These findings demonstrate that incorporation of bidentate phosphine ligands into the Zn(II) coordination sphere significantly influences the structural and antibacterial properties of the resulting complexes.