Publication Details
Abstract
Metabolic syndrome is one of the most common multifactorial disorders associated with obesity, insulin resistance, dyslipidemia, and cardiovascular complications. Chronic stress and hypodynamia are considered important risk factors that aggravate metabolic disturbances and negatively affect liver function. This study aimed to investigate the reactive changes occurring in the liver of rats under the influence of metabolic syndrome induced by various types of stress and hypodynamia. An experimental study was conducted using laboratory rats divided into control and experimental groups. Metabolic syndrome was induced under conditions of chronic stress and reduced physical activity. Histological and morphological analyses were performed to evaluate structural alterations in liver tissues. The obtained results demonstrated significant reactive changes, including hepatocyte degeneration, fatty infiltration, vascular congestion, inflammatory cell infiltration, and signs of oxidative damage. The severity of liver alterations increased when metabolic syndrome was combined with prolonged stress exposure and hypodynamia. The findings indicate that stress and hypodynamia exacerbate metabolic syndrome-associated liver injury and contribute to the progression of hepatic dysfunction. Early prevention of these risk factors may reduce the development of metabolic and hepatic complications.