Publication Details
Abstract
Citrullus colocynthis (L.) Schrader, commonly known as bitter apple or colocynth, is a perennial desert plant of the Cucurbitaceae family that grows in arid and semi-arid regions, including Iraq. This study reviews the environmental parameters influencing its distribution in Iraq and summarizes phytochemical investigations of its fruit, seeds, and aerial parts. Soil salinity, temperature extremes, and moisture availability are key factors affecting C. colocynthis populations in central and southern Iraqi desert zones. Phytochemical screenings have identified cucurbitacins, flavonoids, phenolic acids, and saponins with notable antioxidant and cytotoxic activities. High-performance liquid chromatography (HPLC), gas chromatography–mass spectrometry (GC-MS), and spectrophotometry have been the primary analytical methods employed. Understanding the environmental adaptation and bioactive profile of C. colocynthis supports its potential as a source of natural therapeutics and informs conservation strategies under Iraq’s shifting climate.