A Fruit-Derived Vitamin C–Polyphenol Matrix for Collagen Formation and Tissue Integrity: Stability Characteristics and Human Healing Evidence

The NVTIA® fruit-derived vitamin C-polyphenol powder was evaluated as a stable nutritional input for collagen- and tissue-repair research. The optimized powders contained 16.8-18.4% L-ascorbic acid and 7.9-8.8% corrected total polyphenols, with water activity of 0.23-0.25. After 30 days of accelerated storage, L-ascorbic acid retention was 87.5-89.1%; direct dry mixing, removal of the protective matrix, and a conventional carrier gave lower retention and higher hygroscopicity. Human healing studies are not uniform. A small double-blind trial reported better foot-ulcer healing with 500 mg/day slow-release vitamin C, whereas a pressure-ulcer trial using 500 mg twice daily did not improve wound closure. Multi-nutrient pressure-ulcer studies and collagen-synthesis experiments show that baseline nutrition, wound type, co-interventions, and exposure context materially affect the observed response. The stable fruit-derived matrix is therefore suited to direct studies that pair measured vitamin C exposure with collagen or tissue-integrity endpoints.