Compartment-Resolved Serine Glycine One-Carbon Flux as a Determinant of FSP1-CoQ10 Mediated Ferroptosis Resistance in KRAS/LKB1 Mutant Lung Adenocarcinoma Organoids during Methionine Restriction
Israa Rafi Jamal
Congenital Ferroptosis suppressor protein 1 (FSP1) reduces coenzyme Q10 (CoQ10) to a lipophilic radical-trapping antioxidant and, in parallel with GPX4, protects lung adenocarcinoma (LUAD) from iron-dependent lipid peroxidation. FSP1 is an NAD(P)H...